Markku Laakso Selected Research

PPAR gamma

4/2009	The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinemia in subjects with type 2 diabetes mellitus.
1/2008	SNPs in PPARG associate with type 2 diabetes and interact with physical activity.
10/2007	Atherosclerosis and cardiovascular risk reduction with PPAR agonists.
10/2006	The Pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone-binding globulin level and its relationship to the development of the metabolic syndrome in young Finnish men.
1/2006	Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population.
8/2005	Effect of the Pro12Ala polymorphism of the PPARg2 gene on serum adiponectin changes.
4/2005	Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men.
9/2004	Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis.
7/2004	Interactions between peroxisome proliferator-activated receptor-gamma 2 gene polymorphisms and size at birth on blood pressure and the use of antihypertensive medication.
4/2004	Gene variants, insulin resistance, and dyslipidaemia.

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Markku Laakso Research Topics

Disease

137	Type 2 Diabetes Mellitus (MODY) 10/2023 - 02/2002
115	Insulin Resistance 10/2023 - 01/2002
51	Obesity 01/2024 - 05/2003
43	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2023 - 09/2004
32	Glucose Intolerance 01/2021 - 06/2002
26	Cardiovascular Diseases (Cardiovascular Disease) 01/2024 - 02/2002
21	Hyperglycemia 01/2022 - 07/2003
17	Inflammation (Inflammations) 10/2023 - 10/2007
17	Coronary Disease (Coronary Heart Disease) 01/2019 - 02/2002
14	Hyperinsulinism (Hyperinsulinemia) 01/2021 - 07/2003
13	Coronary Artery Disease (Coronary Atherosclerosis) 01/2019 - 01/2002
10	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 01/2002
10	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2015 - 07/2002
9	Genetic Risk Score 04/2024 - 05/2011
9	Stroke (Strokes) 01/2024 - 10/2005
9	Heart Failure 01/2021 - 05/2004
8	Atherosclerosis 01/2021 - 09/2004
8	Myocardial Infarction 03/2015 - 10/2005
7	Hypertension (High Blood Pressure) 04/2024 - 07/2003
7	Non-alcoholic Fatty Liver Disease 01/2024 - 03/2012
7	Weight Loss (Weight Reduction) 11/2021 - 08/2005
6	Hypertrophy 01/2015 - 01/2003
6	Necrosis 08/2012 - 06/2005
6	Abdominal Obesity 05/2010 - 07/2005
5	Fatty Liver 06/2023 - 10/2011
5	Dyslipidemias (Dyslipidemia) 01/2021 - 05/2003
4	Atherosclerotic Plaque (Atheroma) 01/2021 - 03/2002
4	Overweight 01/2021 - 07/2003
4	Ischemia 01/2017 - 04/2010
4	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/2014 - 08/2005
4	Pre-Eclampsia (Preeclampsia) 09/2006 - 10/2002
3	Ischemic Stroke 01/2024 - 01/2019
3	Hypercholesterolemia 08/2022 - 01/2015
3	Albuminuria 01/2021 - 01/2010
3	Prediabetic State (Prediabetes) 01/2021 - 01/2019
3	Cognitive Dysfunction 10/2020 - 01/2018
3	Cardiomyopathies (Cardiomyopathy) 01/2020 - 01/2004
3	Alcoholic Fatty Liver 05/2016 - 03/2012

Drug/Important Bio-Agent (IBA)

104	Glucose (Dextrose)FDA LinkGeneric 02/2023 - 01/2002
64	Insulin (Novolin)FDA Link 10/2023 - 01/2002
42	LipidsIBA 01/2024 - 02/2002
29	Biomarkers (Surrogate Marker)IBA 06/2023 - 09/2004
23	Proteins (Proteins, Gene)FDA Link 06/2023 - 07/2002
21	CholesterolIBA 01/2017 - 02/2002
20	AdiponectinIBA 10/2023 - 12/2004
19	Triglycerides (Triacylglycerol)IBA 06/2023 - 02/2002
18	Fatty Acids (Saturated Fatty Acids)IBA 12/2022 - 07/2006
13	Messenger RNA (mRNA)IBA 01/2021 - 04/2010
12	C-Reactive ProteinIBA 01/2021 - 12/2004
12	HDL CholesterolIBA 01/2018 - 02/2002
12	Lipoproteins (Lipoprotein)IBA 12/2017 - 02/2002
12	PPAR gammaIBA 04/2009 - 10/2002
10	EnzymesIBA 01/2023 - 01/2011
10	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2023 - 02/2002
10	LDL CholesterolIBA 01/2022 - 02/2002
9	oxidized low density lipoproteinIBA 10/2022 - 04/2004
9	HexokinaseIBA 01/2017 - 07/2005
8	ProinsulinIBA 01/2023 - 09/2009
8	Nonesterified Fatty Acids (NEFA)IBA 01/2021 - 05/2003
8	CytokinesIBA 06/2013 - 07/2003
8	Interleukin-6 (Interleukin 6)IBA 04/2008 - 02/2003
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2010 - 07/2003
6	RNA (Ribonucleic Acid)IBA 01/2024 - 05/2011
6	P-2 (P 2)IBA 02/2023 - 02/2010
6	Linoleic Acid (Linoleate)IBA 10/2022 - 11/2013
6	TropomyosinIBA 09/2014 - 01/2003
6	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 10/2007 - 07/2002
6	Acarbose FDA LinkGeneric 04/2007 - 06/2002
5	Tyrosine (L-Tyrosine)FDA Link 11/2021 - 07/2012
5	Amino Acids FDA Link 11/2021 - 07/2012
5	Alanine (L-Alanine)FDA Link 11/2021 - 10/2006
5	HDL LipoproteinsIBA 01/2018 - 02/2002
4	Leucine (L-Leucine)FDA Link 01/2024 - 03/2002
4	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2024 - 01/2014
4	alpha-Linolenic Acid (Linolenic Acid)IBA 01/2023 - 01/2014
4	Amyloid (Amyloid Fibrils)IBA 01/2023 - 07/2017
4	Simvastatin (Zocor)FDA LinkGeneric 08/2022 - 01/2015
4	Glutamine (L-Glutamine)FDA Link 11/2021 - 07/2012
4	Transcription Factors (Transcription Factor)IBA 01/2021 - 04/2004
4	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2017 - 01/2007
4	Cholestanol (Coprostanol)IBA 08/2010 - 03/2004
3	Branched-Chain Amino AcidsIBA 01/2024 - 01/2015
3	Phosphotransferases (Kinase)IBA 01/2023 - 01/2008
3	Fatty Acid DesaturasesIBA 12/2022 - 01/2019
3	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2021 - 05/2015
3	Phospholipids (Phosphatides)FDA LinkGeneric 01/2021 - 11/2015
3	Hormones (Hormone)IBA 01/2020 - 01/2012
3	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2019 - 06/2013
3	Antihypertensive Agents (Antihypertensives)IBA 01/2019 - 05/2010
3	Glutamic Acid (Glutamate)FDA Link 01/2019 - 02/2015
3	Isoleucine (L-Isoleucine)FDA Link 01/2019 - 07/2012
3	ApolipoproteinsIBA 10/2018 - 06/2011
3	Sirtuin 1IBA 12/2017 - 12/2006
3	Cholesterol Esters (Cholesteryl Esters)IBA 12/2017 - 11/2015
3	DNA (Deoxyribonucleic Acid)IBA 10/2017 - 07/2003
3	trimethyloxamine (trimethylamine N-oxide)IBA 01/2017 - 01/2017
3	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2017 - 03/2012

Therapy/Procedure

5	Glycemic Control 01/2021 - 02/2007
4	Therapeutics 02/2017 - 07/2004
4	Surgical Amputation (Amputations) 03/2015 - 10/2005